논문

1.Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model.
Momoko Kusaki, Yasuyuki Ohta, Haruhiko Inufusa, et al. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1191-1196.

2.Clinical and Pathological Benefit of Twendee X in Alzheimer’s Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1993-2002.

3.Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.
Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, et al. J Alzheimers Dis. 2019;71(3):1063-1069

4.Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer’s Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Oct;28(10):104310.

5.Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements.
Koh Tadokoro, Yasuyuki Ohta, Haruhiko Inufusa, et al. Int J Mol Sci. 2020 Mar;21(6):1974.

6.Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line.
Xiao Hu, Toru Yamashita, Haibo Yu, et al. Neurodegener Dis. 2021;21(5-6):117-125.

7.Effects of Antioxidant composition Twendee X on side effects of SARS-CoV-2 mRNA vaccine.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:1-6.

8.Antioxidant composition Twendee X may improve long COVID symptoms.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:7-12.

9.Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice.
Koji Fukui, Fukka You, Yugo Kato, et al. J Clin Biochem Nutr. March 2023;72(2):93-100.

10.Considering antioxidant supplements as a means to prevent diseases.
Fukka You, Yoshiaki Harakawa, Haruhiko Inufusa. J Neurosci Neurol Disord. 2023;7:14-16.

11.Anti-oxidant, Twendee X, for maintenance of singing voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You, et al. Brain Supplement. 2023;5:1-7.

12.Why Does the Antioxidant Complex Twendee X® Prevent Dementia?
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(16):13018.

13.Potential of an antioxidant combination Twendee X® to treat depressive disorders.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Arch Depress Anxiety. 2023;9(2):68-71.

14.Controlling Gut Microbiota by Twendee X® May Contribute to Dementia Prevention.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(23):16642.

15.The Effect of Oxidative Stress on the Human Voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You. Int J Mol Sci. 2024; 25(5):2604.

16.A Blended Vitamin Supplement Improves Spatial Cognitive and Short-Term Memory in Aged Mice.
Fukui K, You F, Kato Y, et al. Int J Mol Sci. 2024; 25(5):2804.

17.A mixed antioxidant supplement improves cognitive function, and coordination in aged mice.
Koji Fukui, Fukka You, Yugo Kato,et al. J Clin Biochem Nutr. 2024;74(2):119-126.

18.The Potential of Twendee X® as a Safe Antioxidant Treatment for Systemic Sclerosis.
Fukka You, Carole Nicco, Yoshiaki Harakawa, et al. Int J Mol Sci. 2024;25(5):3064.

19.Oxidative Stress and Bio-Regulation. International Journal of Molecular Sciences.
Toshikazu Yoshikawa, Fukka You. 2024; 25(6):3360.

 

문헌

・양복화(楊 馥華), 하라카와 요시테츠(原川 義哲), 히라노 시게루(平野 滋), 요시카와 토시이치(吉川 敏一), 이누후사 하루히코(犬房 春彦), 고령자 의료에 있어서 항산화 보충제의 역할. 노년과, 제5권, 제1호, 19-25 2022.1.

・이누후사 하루히코(犬房 春彦). 궁극의 안티에이징. 청연(青淵), 제863호, 21-23. 2021.2.

 

출원・취득 특허

TIMA재단의 방침하에 이러한 연구 결과는 2014년까지 특허 신청에만 사용되었습니다.
그러나 상당수의 특허를 취득할 수 있었기 때문에, 2014년부터 상기 학회 보고를 개시했습니다.

특허 데이터를 열람하고 싶은 분은 아래의 주요 취득이 끝난 특허를 참조하십시오.
(구글 특허검색에서 제목 혹은 특허번호로 검색 가능합니다.현재도 다수의 국제특허를 신청중입니다.)

  • ・일본특허청 특허 제5777821호 세포 장애 작용을 방어하기 위한 조성물
  • ・일본특허청 특허 제5785581호 알코올 대사 완화 및 알코올 유발성 질환 위험 감소를 위한 조성물
  • ・Alcohol metabolism moderating composition WO 2005077464 A1
  • ・Novel compositions and uses thereof WO 2008071790 A3
  • ・Antioxidant composition and its use in diabetes EP 1932542 A1
  • ・Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8
  • ・Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1
  • ・Optimized oral glucose tolerance test US 7886697 B2
  • ・Compositions and uses thereof US 8633192 B2