Research Presentation

Research Presentation

 

Thesis

1.Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model.
Momoko Kusaki, Yasuyuki Ohta, Haruhiko Inufusa, et al. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1191-1196.

2.Clinical and Pathological Benefit of Twendee X in Alzheimer’s Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1993-2002.

3.Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.
Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, et al. J Alzheimers Dis. 2019;71(3):1063-1069

4.Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer’s Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Oct;28(10):104310.

5.Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements.
Koh Tadokoro, Yasuyuki Ohta, Haruhiko Inufusa, et al. Int J Mol Sci. 2020 Mar;21(6):1974.

6.Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line.
Xiao Hu, Toru Yamashita, Haibo Yu, et al. Neurodegener Dis. 2021;21(5-6):117-125.

7.Effects of Antioxidant composition Twendee X on side effects of SARS-CoV-2 mRNA vaccine.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:1-6.

8.Antioxidant composition Twendee X may improve long COVID symptoms.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:7-12.

9.Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice.
Koji Fukui, Fukka You, Yugo Kato, et al. J Clin Biochem Nutr. March 2023;72(2):93-100.

10.Considering antioxidant supplements as a means to prevent diseases.
Fukka You, Yoshiaki Harakawa, Haruhiko Inufusa. J Neurosci Neurol Disord. 2023;7:14-16.

11.Anti-oxidant, Twendee X, for maintenance of singing voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You, et al. Brain Supplement. 2023;5:1-7.

12.Why Does the Antioxidant Complex Twendee X® Prevent Dementia?
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(16):13018.

13.Potential of an antioxidant combination Twendee X® to treat depressive disorders.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Arch Depress Anxiety. 2023;9(2):68-71.

14.Controlling Gut Microbiota by Twendee X® May Contribute to Dementia Prevention.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(23):16642.

15.The Effect of Oxidative Stress on the Human Voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You. Int J Mol Sci. 2024; 25(5):2604.

16.A Blended Vitamin Supplement Improves Spatial Cognitive and Short-Term Memory in Aged Mice.
Fukui K, You F, Kato Y, et al. Int J Mol Sci. 2024; 25(5):2804.

17.A mixed antioxidant supplement improves cognitive function, and coordination in aged mice.
Koji Fukui, Fukka You, Yugo Kato,et al. J Clin Biochem Nutr. 2024;74(2):119-126.

18.The Potential of Twendee X® as a Safe Antioxidant Treatment for Systemic Sclerosis.
Fukka You, Carole Nicco, Yoshiaki Harakawa, et al. Int J Mol Sci. 2024;25(5):3064.

19.Oxidative Stress and Bio-Regulation. International Journal of Molecular Sciences.
Toshikazu Yoshikawa, Fukka You. 2024; 25(6):3360.

 

Literature

・Yang Fuhua, Yoshitsu Haragawa, Hirano Shizuo, Toshikazu Yoshikawa, Haruhiko Inufusa.The role of antioxidant nutritional supplements in the medical care of the elderly. Geriatrics, Volume 5, Number 1, 19- 25.2022.1.

・Haruhiko Inufusa.The ultimate anti-aging. Qingyuan, No. 863, 21-23. 2021.2.

 

Patent

Under the policy of TIMA establishment, these research results were only used for patent applications before 2014.However, since a considerable number of patents have been obtained, the above Institute report has been started since 2014.

If you want to check the patent data, please refer to the main patents obtained below.
(在Title or patent number can be retrieved in Google’s patent search.At present, also a number of international patents are being applied for.）

  • ・Japanese Patent Office patent No. 5777821 Compounds for defense against cellular disorders
  • ・Japanese Patent Office patent No. 5785581 Compounds used to slow alcohol metabolism and reduce the risk of alcohol induced diseases
  • ・Alcohol metabolism moderating composition WO 2005077464 A1
  • ・Novel compositions and uses thereof WO 2008071790 A3
  • ・Antioxidant composition and its use in diabetes EP 1932542 A1
  • ・Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8
  • ・Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1
  • ・Optimized oral glucose tolerance test US 7886697 B2
  • ・Compositions and uses thereof US 8633192 B2