Centered on the Antioxidant Research Department of Gifu University and the Louis Pasteur Medical Research Center Antioxidant Research Center, where Haruhiko Inufusa is in charge of development, we are cooperating with research institutions and researchers from all over the world, aiming to lead the world’s research and development.
The research results are published in papers and society publications.
■Gifu University Scientific Research Foundation Center Joint Research Lecture Antioxidant Research Department
■Public welfare consortium legal person Louis Pasteur Medical Research Center Antioxidant Laboratory
Under the policy of TIMA establishment, these research results were only used for patent applications before 2014.However, since a considerable number of patents have been obtained, the above Institute report has been started since 2014.
If you want to check the patent data, please refer to the main patents obtained below.
(在Title or patent number can be retrieved in Google’s patent search.At present, also a number of international patents are being applied for.）
- ・Japanese Patent Office patent No. 5777821 Compounds for defense against cellular disorders
- ・Japanese Patent Office patent No. 5785581 Compounds used to slow alcohol metabolism and reduce the risk of alcohol induced diseases
- ・Alcohol metabolism moderating composition WO 2005077464 A1
- ・Novel compositions and uses thereof WO 2008071790 A3
- ・Antioxidant composition and its use in diabetes EP 1932542 A1
- ・Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8
- ・Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1
- ・Optimized oral glucose tolerance test US 7886697 B2
- ・Compositions and uses thereof US 8633192 B2
・Fukka You, Sho Tanaka, Toshikazu Yoshikawa, Markus Matuschka von Greiffenclau, and Haruhiko Inufusa.Antioxidant composition Twendee X may improve long COVID symptoms. Brain Supplement (ISSN 2434-9615) 2022.4.5
・Fukka You, Sho Tanaka, Toshikazu Yoshikawa, Markus Matuschka von Greiffenclau, and Haruhiko Inufusa. Effects of Antioxidant composition Twendee X on side effects of SARS-CoV-2 mRNA vaccine. Brain Supplement (ISSN 2434-9615) 2022.3.16
・Yang Fuhua, Sho Tanaka, Markus Count Matuschka de Greiffenclau, Toshikazu Yoshikawa, Okada Naomi, Haruhiko Inufusa.Antioxidant Twendee X challenges geriatric Medicine — the future of preventive Medicine in terms of achieving the world’s first prevention of cognitive dysfunction — Precision Medicine. May 2021; 4 (5) : 447-452.
・Yang Fuhua, Sho Tanaka, Markus Count Matuschka de Greiffenclau, Toshikazu Yoshikawa, Okada Naomi, Haruhiko Inufusa.Achieve the world’s first antioxidant to prevent cognitive impairment – antioxidant Tweedee x challenges the super elderly society – BIO Clinica Vol.35 No.10 Sep. 2020.
・Yang Fuhua, Sho Tanaka, Markus Count Matuschka de Greiffenclau, Toshikazu Yoshikawa, Okada Naomi, Haruhiko Inufusa.Achieve the world’s first prevention of cognitive impairment – the association with oxidative stress, inflammation and immunity. BIO Clinica Vol.35 No.4 Apr. 2020.
・Koh Tadokoro, Yasuyuki Ohta, Haruhiko Inufusa, Alan Foo Nyuk Loon, Koji Abe. Prevention of Cognitive De-cline in Alzheimer’s Disease by Novel Antioxidative Supplements. Int J Mol Sci. 2020 Mar; 21(6)
・Yang Fuhua, Sho Tanaka, Markus Count Matuschka de Greiffenclau, Toshikazu Yoshikawa, Okada Naomi, Haruhiko Inufusa.Achieve the world’s first case of prevention of cognitive impairment (through the antioxidant research department’s adjuvant tweedex to prevent cognitive impairment). Medical Science Digest, Vol45(13), 2019.11.
・Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, Nozomi Hishikawa, Satoko Kawano, Ryo Sasaki, NamikoMatsumoto, Emi Nomura, Yumiko Nakano, Yoshiaki Takahashi, Mami Takemoto, Toru Yamashita, Setsuko Ueno, Yosuke Wakutani, Yoshiki Takao, Nobutoshi Morimoto, Yumiko Kutoku, Yoshihide Sunada, Katsushi Taomoto, Yasuhiro Manabe, Kentaro Deguchi, Yasuto Higashi, Haruhiko Inufusa, Fukka You, Toshikazu Yoshikawa, Markus Matuschka von Greiffenclau, Koji Abe. Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Place-bo-Controlled Prospective Interventional Study. J Alzheimers Dis. 2019; 71(3): 1063-1069
・Hirano Shizuo, Haruhiko Inufusa, Sugiyama Yuichiro, Kaneko Mami, Toshikazu Yoshikawa.Voice and Anti-aging, Journal of the Japanese Anti-aging Medical Association, Vol. 15, No. 2, 214-219. 2019.4.
・Momoko Kusaki, Yasuyuki Ohta, Haruhiko Inufusa, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Xia Liu, Jingwei Shang, Feng Tian, Yusuke Fukui, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Koji Abe.Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1191-1196.
・Yang Fuhua, Yoshitsu Haragawa, Hirano Shizuo, Toshikazu Yoshikawa, Haruhiko Inufusa.The role of antioxidant nutritional supplements in the medical care of the elderly. Geriatrics, Volume 5, Number 1, 19- 25.2022.1.
・Haruhiko Inufusa.The ultimate anti-aging. Qingyuan, No. 863, 21-23. 2021.2.