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SUPALIV

main product
SUPALIV is TIMA Group’s first product selling in Japanese market.

Innovative supplement, whose component combination acts to alcohol metabolic cycle.

SUPALIV birth story

In 2003, at the harvest festival in famous winery of Count de Greiffenclau. A Japanese lady consulted with Markus Count Matuschka de Greiffenclau, host of the harvest festival. She loves wine but gets drunk soon.

Markus Count Matuschka knew that asian people are weak to drink alcohol and some of them cannot drink at all. He made a proposal to develop a supplement which would permit weak people to drink to enjoy wines.

Markus Count Matuschka consulted with his friend Haruhiko Inufusa (Physician, doctor of medicine) about developing an alcohol metabolism supplement. Dr. Inufusa, who presented papers about the workings of alcohol and immune cells at academic conferences at that time, started to research alcohol metabolism.

After that, the research and development team led by Dr. Inufusa performed lots of clinical researches and acquired several patents.

SUPALIV was commercialized in 2011 and was on sell in Japan.

Package Design

Mr. Issei Kitagawa　(GRAPH head designer）

カンブリア宮殿（テレビ東京）をはじめ、NHK やフジテレビの番組にも多数出演。

Appeared on TV program “Cambria Palace” (TV Tokyo) and NHK and Fuji Television Network TV programs many times.
Member of Alliance Graphique Internationale, the world’s best designers’ organization.
JAGDA new face award, TDC award and many other awards.
By pursing arts of “printings that cannot be abandoned” and proposing “design as management resources” in stand on the point of views of both of manager and designer, he is supported by lots of clients from local small and medium-sized enterprises to foreign famous luxury brands.

About Crest

On SUPALIV’s package, the crest of Count de Greiffenclau, who has carried on wine making from the age of Charlemagne, is printed.
This is because the research and development of SUPALIV were started by the proposal of Markus Count Matuschka de Greiffenclau, present chief director at European Medical Foundation TIMA Foundation and head of Count de Greiffenclau.

グライフェンクラウ伯爵家紋章

Lineup

3 tablets

3 tablets

10 tablets

10 tablets

20 tablets

20 tablets

100 tablets bottle

100 tablets bottle

SUPALIV Related Sites

brand website

e-commerce website

e-commercein english for overseas

 

Oxicut

main product

Oxicut 90 tablets

Oxicut was born from antioxidant researches in German and Japanese universities.

Anti-aging supplement developed by the physician who has conduted antioxidant research for many years.
“Oxicut” was developed by the team led by Dr. Haruhiko Inufusa, specially appointed professor at the antioxidant division of Life Science Research Center, Gifu University. ICDD (French oxidative stress measuring company) certified Oxicut as the most antioxidant product in the world.

オキシカット（Oxicut）アドバイザー

Test data

November 2007 Download PDF file “Twendee diabetes patients 3-months administration side effect survey”

November 2007 Download PDF file “Twendee toxicity test”

October 2007 Download PDF file “Twendee mutation test”

August 2007 Download PDF file “Twendee chromosomal aberration test”

May 2007 Download PDF file “Twendee toxicity preliminary test”

Related Research

June 2021 第10回日本認知症予防学会学術集会”認知症予防の最先端”

September 2020 　第61回日本神経学会学術大会”脳神経疾患の抗酸化治療 ー Twendee X 無限大の可能性ー”

October 2019 　第1回日本脳サプリメント学会”抗酸化サプリメント Twendee Xの臨床効果”

December 2015 The 13th Meeting for Medical Use of Functional Foods, Fukuoka “Measuring Antioxidant Activity of Oxicut”.

November 2015 The 70th Meeting of the Coloproctology desease, Nagoya, Japan “Basic experiments of ulcerative colitis treatment with Oxicut, a new oxidative stress reduction combined supplement”.

June 2014 “Antioxidant effect that Oxicut gives to mouse radiation oxidative stress model”.

Oxicut Related Sites

e-commerce website in Japan

e-commercein english for overseas

 

Mtcontrol

ミトコントロール（Mtcontrol

Mtcontrol 100 tablets

オキシカットに、７つの新成分をプラス
「ミトコントロール（Mtcontrol） 」

ビタミンC、ビタミンB群、アミノ酸、ラクトフェリンなど15種類の有用成分がバランスよく配合されたサプリメントです。

Mtcontrol Related Sites

e-commerce website in Japan

e-commercein english for overseas

 

About TIMA Japan Quality

main product

All the TIMA Japan products are certified to have effectiveness by a third party. Further, safety test, which is not ordinarily required for supplements, was also performed. We manufacture and sell only products with medically-proven effect (with evidence).

Safety test performed

Safety test, ordinarily required only for pharmaceuticals, was performed by Ina Research Inc. (safety test trustee company, listed on the Tokyo Stock Exchange) in 2007 and all the tests conducted have reported SUPALIV is safe.

Effect by one week repeated administration in rats
Ina Research
Test number:GL43080
Chromosomal aberration test using cultured mammalian cells
Ina Research
Test number:BV07158
Four-weeks repeated oral toxicity study in rats
Ina Research
Test number:BV07156
Reverse mutation test using bacterium (excluding cystine)
Ina Research
Test number:BV07352

Human clinical trial performed

We have performed fundamental researches, animal experiments and human clinical trials about SUPALIV, and have given papers on these results at the 14th Anti-Aging Medicine meeting, the 12th Oxidative Stress and Antioxidant Seminar and other meetings.
Further, human clinical trial was performed by Allegro.Inc (subsidiary company of leading clinical examination company BML). The trial was performed twice in 2008 for cases of drinking vodka and wine.
Clinical trial’s result is here. →Clinical Trial Result

International Patent Acquired

Large number of international patents relating to SUPALIV and Twendee X are acquired or applied. International Patent System (PCT) is useful in requesting international patent protection of applicant’s own invention(s). By applying one international patent, it becomes possible to request invention protection in 148 countries in the world at the same time.
About details of international patent, please refer to the following.
→ Acquired Patents

Research Presentation
Patent
News