论 文

1.Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model.
Momoko Kusaki, Yasuyuki Ohta, Haruhiko Inufusa, et al. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1191-1196.

2.Clinical and Pathological Benefit of Twendee X in Alzheimer’s Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1993-2002.

3.Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.
Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, et al. J Alzheimers Dis. 2019;71(3):1063-1069

4.Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer’s Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Oct;28(10):104310.

5.Prevention of Cognitive Decline in Alzheimer’s Disease by Novel Antioxidative Supplements.
Koh Tadokoro, Yasuyuki Ohta, Haruhiko Inufusa, et al. Int J Mol Sci. 2020 Mar;21(6):1974.

6.Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line.
Xiao Hu, Toru Yamashita, Haibo Yu, et al. Neurodegener Dis. 2021;21(5-6):117-125.

7.Effects of Antioxidant composition Twendee X on side effects of SARS-CoV-2 mRNA vaccine.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:1-6.

8.Antioxidant composition Twendee X may improve long COVID symptoms.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:7-12.

9.Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice.
Koji Fukui, Fukka You, Yugo Kato, et al. J Clin Biochem Nutr. March 2023;72(2):93-100.

10.Considering antioxidant supplements as a means to prevent diseases.
Fukka You, Yoshiaki Harakawa, Haruhiko Inufusa. J Neurosci Neurol Disord. 2023;7:14-16.

11.Anti-oxidant, Twendee X, for maintenance of singing voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You, et al. Brain Supplement. 2023;5:1-7.

12.Why Does the Antioxidant Complex Twendee X® Prevent Dementia?
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(16):13018.

13.Potential of an antioxidant combination Twendee X® to treat depressive disorders.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Arch Depress Anxiety. 2023;9(2):68-71.

14.Controlling Gut Microbiota by Twendee X® May Contribute to Dementia Prevention.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(23):16642.

15.The Effect of Oxidative Stress on the Human Voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You. Int J Mol Sci. 2024; 25(5):2604.

16.A Blended Vitamin Supplement Improves Spatial Cognitive and Short-Term Memory in Aged Mice.
Fukui K, You F, Kato Y, et al. Int J Mol Sci. 2024; 25(5):2804.

17.A mixed antioxidant supplement improves cognitive function, and coordination in aged mice.
Koji Fukui, Fukka You, Yugo Kato,et al. J Clin Biochem Nutr. 2024;74(2):119-126.

18.The Potential of Twendee X® as a Safe Antioxidant Treatment for Systemic Sclerosis.
Fukka You, Carole Nicco, Yoshiaki Harakawa, et al. Int J Mol Sci. 2024;25(5):3064.

19.Oxidative Stress and Bio-Regulation. International Journal of Molecular Sciences.
Toshikazu Yoshikawa, Fukka You. 2024; 25(6):3360.

 

文 献

・馥华、原川义哲、平野滋、吉川敏一、犬房春彦。抗氧化健康食品在老年人医疗中的作用。老年科,第5卷,第1号,19- 25.2022.1。

・犬房春彦。终极的抗衰老。青渊,第863号,21-23. 2021.2。

 

申请・取得专利

在TIMA财团的方针下,这些研究结果在2014年之前仅用于专利申请。
但是由于取得了相当数量的专利,因此从2014年开始了上述的学会报告。

如果您想查阅专利数据,请参见以下已获得的主要专利。
(在Google的专利检索中可以检索标题或专利号。目前也有多项国际专利正在申请中。)

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  • ・Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8
  • ・Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1
  • ・Optimized oral glucose tolerance test US 7886697 B2
  • ・Compositions and uses thereof US 8633192 B2